Hemoglobin a1c normal range for men9/22/2023 Blood HbA1c is a mean for RBCs with values that range from very low for reticulocytes to approximately twice the mean for the oldest RBCs. The hemoglobin A1c (HbA1c) determination used clinically to evaluate glycemic control depends on 3 factors: (1) the HbA1c in reticulocytes when they are released from the bone marrow (2) the synthetic rate of HbA1c (or Hb glycation rate) as red blood cells (RBCs) become older, a function of glucose concentration to which Hb is exposed and (3) the mean age of RBCs in the circulation. The observed variation in RBC survival was large enough to cause clinically important differences in HbA1c for a given mean blood glucose. HbA1c synthesis was linear and correlated with mean whole blood HbA1c (R 2 = 0.91). The mean age of circulating RBCs ranged from 39 to 56 days in diabetic subjects and 38 to 60 days in nondiabetic controls. In addition, HbA1c in magnetically isolated labeled RBCs and in isolated transferrin receptor-positivereticulocytes was used to determine the in vivo synthetic rate of HbA1c. Mean RBC age was calculated from the RBC survival curve for all circulating RBCs and for labeled RBCs at multiple time points as they aged. To explore the hypothesis that variation in RBC life span could alter measured HbA1c sufficiently to explain some of this discordance, we determined RBC life span using a biotin label in 6 people with diabetes and 6 nondiabetic controls. However, an unexplained discordance between HbA1c and other measures of glycemic control can be observed that could be, in part, the result of differences in RBC life span. For additional information visit Linking to and Using Content from MedlinePlus.Although red blood cell (RBC) life span is a known determinant of percentage hemoglobin A1c (HbA1c), its variation has been considered insufficient to affect clinical decisions in hematologically normal persons. Any duplication or distribution of the information contained herein is strictly prohibited without authorization. Links to other sites are provided for information only - they do not constitute endorsements of those other sites. A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. This site complies with the HONcode standard for trustworthy health information: verify here. Learn more about A.D.A.M.'s editorial policy editorial process and privacy policy. is among the first to achieve this important distinction for online health information and services. follows rigorous standards of quality and accountability. is accredited by URAC, for Health Content Provider (URAC's accreditation program is an independent audit to verify that A.D.A.M. Are taking certain medicines, such as dapsone, erythropoietin, or ironĪ.D.A.M., Inc.Have conditions such as kidney disease, sickle cell disease, anemia, or thalassemia.Do not use eAG to evaluate your diabetes control if you: There are many medical conditions and medicines that change the relationship between A1c and eAG. Your doctor should never tell you what your blood sugar values are based on the eAG because the range of average blood glucose for any individual person is very broad for each A1c level. The value is only an estimate. So, the average of your results on your meter may be different than your eAG. But it does not show your blood sugar at other times of the day. This is because you are likely to check your sugar levels before meals or when your blood sugar levels are low. The results of an eAG test may not match your average of day-to-day blood sugar tests you have been taking at home on your glucose meter. A person with diabetes should aim for an eAG less than 154 mg/dl (A1C < 7%) to lower the risk for diabetes complications. The normal value for eAG is between 70 mg/dl and 126 mg/dl (A1C: 4% to 6%).
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